Download e-book for iPad: Adult Stem Cells: Biology and Methods of Analysis by David M. Panchision (auth.), Donald G. Phinney (eds.)

By David M. Panchision (auth.), Donald G. Phinney (eds.)

ISBN-10: 161779001X

ISBN-13: 9781617790010

This is complete review of an essential region of medical enquiry, which covers a huge spectrum of matters. With contributions from a few of the key researchers within the box, grownup Stem Cells: Biology and strategies of research deals readers a ancient viewpoint in addition to exact insights into state of the art strategies. the quantity contextualizes the hot discovery of stem/progenitor mobilephone populations resident in lots of grownup tissues and organs. It confronts the complexities scientists face in attempting to validate those cells, whereas it additionally describes and seriously evaluates the equipment presently used to evaluate stem cellphone self-renewal. The chapters additionally search to differentiate this strategy from different points of telephone survival, corresponding to the law of existence span, senescence, and immortalization at a molecular point.

The monograph starts with a bit that research the elemental biology of grownup stem cells, together with chapters at the rising position of microRNAs in regulating their destiny and the molecular mechanisms that govern their self-renewal, the ebook strikes directly to learn the various methodologies hired in characterizing those elusive parts of our genetic makeup. the second one part info in-vivo lineage tracing of tissue-specific stem cells, explores the neural stem mobilephone paradigm, and considers the functionality of ABC transporters and aldehyde dehydrogenase in grownup stem-cell biology. the ultimate part shifts the focal point to the life-span legislation and immortalization and lines a bankruptcy at the melanoma stem mobile paradigm.

This is an authoritative quantity on one of many frontiers of genetic learn, and should function a worthwhile source, not only for tested scientists but additionally for these now coming into the sphere of stem telephone biology.

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Additional resources for Adult Stem Cells: Biology and Methods of Analysis

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Fasano CA, Dimos JT, Ivanova NB et al (2007) shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development. Cell Stem Cell 1:87–99. Fasano CA, Phoenix TN, Kokovay E et al (2009) Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain. Genes Dev 23:561–574. Favaro R, Valotta M, Ferri AL et al (2009) Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci 12:1248–1256.

However, this exact property has been exploited to study the underlying molecular mechanisms of fate specification and to reprogram cells for therapeutic purposes. References Aguirre A, Dupree JL, Mangin JM et al (2007) A functional role for EGFR signaling in myelination and remyelination. Nat Neurosci 10:990–1002. Ahn S, Joyner AL (2005) In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 437:894–897. Alvarez-Buylla A, Kohwi M, Nguyen TM et al (2008) The heterogeneity of adult neural stem cells and the emerging complexity of their niche.

This is being done extensively in embryonic stem cells to identify candidate molecules and gene regulatory networks controlling “stemness,” a core program underlying self-renewal and potency. Other efforts are comparing embryonic and tissue-specific adult stem cells in order to distinguish global stem cell programs from tissue-specific stem cell programs (Muller et al. 2008). The combination of global phenotyping and functional characterization of individual genes will yield a more integrative picture of the cellular properties of self-renewal and potency and the environmental signals that regulate them (Chambers and Tomlinson 2009; Chen et al.

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Adult Stem Cells: Biology and Methods of Analysis by David M. Panchision (auth.), Donald G. Phinney (eds.)


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