Read e-book online Advances in Immunology 50 PDF

By Frank J. Dixon

ISBN-10: 012022450X

ISBN-13: 9780120224500

The fiftieth quantity in a monographic sequence on immunology. one of the themes coated listed below are avian T-cell ontogeny, adoptive move of human lymphoid cells to critically immuno-deficient mice and histamine-releasing components and cytokine-dependent activation of basophils and mast cells.

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Alternatively, binding to the MHC may lead to an alteration in the conformation of SEs, allowing them to bind to V p directly, whereas the unmodified SE cannot. This seems unlikely as well, because the SEs appear to be very tightly packed, rigid molecules. A third possibility is that the SEs activate €3 cells in such a way that they stimulate potent T cell responses. , 1989; Macphail and Stutman, 1990) can present SEs to T cells. The second major problem with the working model is the failure to Vp SELECTIVE ELEMENTS 43 detect the products ofthe Vbse.

The VP-encoded portion of the TCR is the critical element in inducing T cell responses to Vbse. In addition, the CD4 coreceptor plays a critical role in most murine T cell responses to peptides presented by MHC class 11, increasing sensitivity . , 1 9 8 9 ~ )In section, the contributions of the elements of the T cell receptor to responses to Vbse will be explored. 1 . However, as the precursor frequency was so high, it was difficult to believe that the same receptor that recognized antigen could also recognize Mls.

JANEWAY, JR 3 . The Transfer of Vbse between Cells As mentioned above, T cells do not stimulate primary proliferative responses to Vbse. Because murine T cells do not express class I1 MHC, it may be that T cells express the Vbse but cannot present it to other T cells in a stimulatory form. , 1990; Webb and Sprent, 1990). If this were the case, one might expect to find other aspects of this transfer in uiuo or in uitro, such as induction of stimulatory capacity in mixed chimeras or in tissue culture.

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Advances in Immunology 50 by Frank J. Dixon


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