By Frank J. Dixon and Henry G. Kunkel (Eds.)
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Extra resources for Advances in Immunology, Vol. 24
It is anticipated that classical and alternative pathway C5a will be chemically and biologically identical. Chemotactic activity due to C5a and the C5b,6,7 complex can be generated by activators of the classical and the alternative pathways (228, 256-258) and can be produced in CCdeficient guinea pig and human C2-deficient sera (36, 73, 217) by CVF (227) and by activators of the properdin system (36, 217). In addition, chemotactic activity for human neutrophile polymorphonuclear leukocytes has been generated in mixtures of CVF and Factors B and D or C3b and Factors B and D (210).
32 0. GOTZE AND H. J. M ~ L E R - E B E R H A R D 165. Miiller-Eberhard, H. , Spiegelberg, H. , unpublished observations. 166. Muller-Eberhard, H. , Nilsson, U. , Dalmasso, A. , Polley, M. , and Calcott, M. A. Arch. Pathol. 82, 205. 167. Muschel, L. , Chamberlin, R. , and Osawa, E. (1958). Proc. Erp. Biol. Med. 97, 376. 168. Muschel, L. , and Webb, P. M. (1964). SOC. Exp. Biol. Med. 117, 639. 169. Naff, G. , Todd, E. , Novak, M. A,, and Ratnoff, W. D. (1975). Fed. , Fed. Am. Soc. Exp. Biol. 34, 955.
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Advances in Immunology, Vol. 24 by Frank J. Dixon and Henry G. Kunkel (Eds.)