By Robin Holliday
For hundreds of years humans were wondered via the inevitability of human getting older. for many of the second one 1/2 the 20 th century getting older remained a secret, or an unsolved organic challenge. on the finish of the twentieth century a extraordinary medical discovery emerged. It was once no longer a unmarried discovery within the ordinary experience, since it was once in accordance with a chain of vital interconnected insights over relatively an extended time period. those insights made it attainable for the first actual time to appreciate the organic purposes for getting older in animals and guy. it will possibly already be stated, besides the fact that, that the numerous observations and insights that designate getting older are usually not authorized as tested wisdom for a very long time. the sphere continues to be filled with scientists, and non-scientists, who're simply satisfied to head on speculating concerning the 'mystery' of getting older. the purpose of this e-book is to dispel lack of awareness via explaining in non-technical language what are the explanations for getting older and the parable of over the top prolongation of existence.
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Extra resources for Aging: The Paradox of Life
In fact, the history of this field of study is characterised by the overstatement of the importance of each theory. Thus, the proposer of a particular theory often claims that it explains the whole of ageing. What is striking that each theory can usually related to a particular cause of ageing, or to a failure of one of the maintenance mechanisms summarised in Chapter 3. For example, the somatic mutation theory proposes that changes in DNA are the cause of ageing. The mitochondial theory of ageing is even more specific in that is asserts that the loss of mitochondrial function is the cause of ageing.
The immune system consists of many different components, which must operate as an integrated unit. It is well known that the efficiency of immunity declines with age, probably because individual components are not making their normal contribution to the whole. Old people become more susceptible to infections such as influenza or pneumonia. Multiple Causes 29 The immune system is capable of distinguishing self from non-self, and that is why grafts of tissue from other individuals are destroyed. Autoimmune diseases are due to a breakdown of the recognition of self cells or tissues.
Thus, insulin controls the level of glucose in the blood. There are two types of diabetes, one of which can be of early onset, and is due to the loss of the cells that synthesise insulin. This type of diabetes can be controlled by the injection of the hormone, but these diabetics die about 15 years earlier than the average lifespan. The other type is called ‘late-onset’ because it becomes much more common in older people, especially if they are obese. This is due to abnormalities in insulin metabolism, for example, an insufficiency in synthesis, or just as likely, changes in the cells that normally respond to insulin.
Aging: The Paradox of Life by Robin Holliday