Download PDF by George Tegos, Eleftherios Mylonakis: Antimicrobial drug discovery : emerging strategies

By George Tegos, Eleftherios Mylonakis

ISBN-10: 1845939433

ISBN-13: 9781845939434

Drug resistance is expanding between quite a few human pathogenic microorganisms comparable to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as probably the most very important scientific demanding situations of this century. elevated common know-how and worry of those pathogens capability there's a becoming call for for examine to take on the specter of multidrug resistance. Documenting the newest study within the box, this ebook discusses present and promising actions to find new antimicrobials in 5 key parts: molecular genetics and platforms microbiology; man made, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and light-weight- and nano-based applied sciences.

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And Sharma, S. (2009) Peptide deformylase – a promising therapeutic target for tuberculosis and antibacterial drug discovery. Expert Opinion on Therapeutic Targets 13, 753–765. P. R. P. R. (2011) Drug discovery of antimicrobial photosensitizers using animal models. Current Pharmaceutical Design 17, 1303–1319. M. B. (2003) Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infection and Immunity 71, 2208–2217. , Begun, J. M. (2005) The worm has turned – microbial virulence modeled in Caenorhabditis elegans.

2008) A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science 319, 1391–1394. Loeffler, J. A. (2003) Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillinsensitive and -resistant Streptococcus pneumoniae strains. Antimicrobial Agents and Chemotherapy 47, 375–377. , Djurkovic, S. A. (2003) Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia. Infection and Immunity 71, 6199–6204. Lomovskaya, O.

Mylonakis, E. R. (2010) Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model. Lasers in Surgery and Medicine 42, 38–44. Daum, R. (2008) Removing the golden coat of Staphylococcus aureus. New England Journal of Medicine 359, 85–87. N. F. (2010) Community-associated meticillinresistant Staphylococcus aureus. Lancet 375, 1557–1568. L. and Sanchez, S. (2009) Microbial drug discovery: 80 years of progress. Journal of Antibiotics 62, 5–16. Demidova, T.

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Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis


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