Download PDF by George Tegos, Eleftherios Mylonakis: Antimicrobial drug discovery : emerging strategies

By George Tegos, Eleftherios Mylonakis

ISBN-10: 1845939433

ISBN-13: 9781845939434

Drug resistance is expanding between quite a few human pathogenic microorganisms comparable to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as probably the most very important scientific demanding situations of this century. elevated common know-how and worry of those pathogens capability there's a becoming call for for examine to take on the specter of multidrug resistance. Documenting the newest study within the box, this ebook discusses present and promising actions to find new antimicrobials in 5 key parts: molecular genetics and platforms microbiology; man made, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and light-weight- and nano-based applied sciences.

Show description

Read Online or Download Antimicrobial drug discovery : emerging strategies PDF

Best basic science books

Download e-book for iPad: Lactic Acid Bacteria: Microbiological and Functional by Seppo Salminen, Atte von Wright

Whereas lactic acid generating fermentation has been applied to enhance the storability, palatability, and nutritive price of perishable meals for a long time, just recently have we started to appreciate simply why it really works. the 1st variation of this overseas bestseller either estimated and inspired lively learn of assorted traces of lactic acid micro organism that allows you to substantiate a lot of what was once identified yet by no means scientifically demonstrated.

Lipidomics and bioactive lipids: mass-spectrometry-based by H. Alex Brown PDF

This quantity within the well-established equipment in Enzymology sequence good points equipment for the research of lipids utilizing mass spectrometry recommendations. Articles during this quantity conceal subject matters similar to Qualitative research and Quantitative overview of adjustments in impartial Glycerol Lipid Molecular Species inside Cells; Glycerophospholipid id and quantitation through electrospray ionization mass spectrometry; Detection and Quantitation of Eicosanoids through excessive functionality Liquid Chromatography/Electrospray Ionization Mass Spectrometry; Structure-specific, quantitative equipment for "lipidomic" research of sphingolipids by means of tandem mass spectrometry; research of Ubiquinones, Dolichols and Dolichol Diphosphate-Oligosaccharides by means of Liquid Chromatography Electrospray Ionization Mass Spectrometry; Extraction and research of Sterols in organic Matrices by means of High-Performance Liquid Chromatography Electrospray Ionization Mass Spectrometry; The Lipid Maps Initiative in Lipidomics; simple analytical structures for lipidomics by means of mass spectrometry in Japan; the eu Lipidomics Initiative allowing applied sciences; Lipidomic research of Signaling Pathways; Bioinformatics for Lipidomics; Mediator Lipidomics: seek Algorithms for Eicosanoids, Resolvins and Protectins; A advisor to biochemical platforms modeling of sphingolipids for the biochemist; and Quantitation and Standardization of Lipid inner criteria for Mass Spectroscopy.

Download PDF by George A. Bray, Claude Bouchard: Handbook of Obesity: Etiology and Pathophysiology, Second

Delivering views at the historical past, occurrence and genetics of weight problems, this e-book examines the origins and etiology of weight problems. It considers the connection among behavioural neuroscience and obesity.

Table of Contents

History, Definitions, and occurrence - old Framework for the improvement of rules approximately weight problems George A. Bray, evaluate of overall and local Adiposity, Steven B. Heymsfield, Richard N. Baumgartner, David B. Allison, ZiMian Wang, and Robert Ross, Ethnic and Geographic impacts on physique Composition Paul Deurenberg and Mabel Deurenberg-Yap; incidence of weight problems in Adults - the worldwide Epidemic, Jacob C. Seidell and Aila M. Rissanen; The Fetal Origins of weight problems, David J. P. Barker; Pediatric weight problems - an summary, Bettylou Sherry and William H. Dietz; weight problems within the aged - incidence, outcomes, and therapy Robert S. Schwartz; financial expenditures of weight problems Ian D. Caterson, Janet Franklin, and Graham A. Colditz; Etiology; Genetics of Human weight problems Claude Bouchard, Louis P russe, Treva Rice, and D. C. Rao; Molecular Genetics of Rodent and Human unmarried Gene Mutations Affecting physique Composition Streamson C. Chua, Kathleen Graham and Rudolph L. Leibel; Rodent versions of weight problems David A. York; Primates within the learn of Aging-Associated weight problems Barbara C. Hansen; Behavioral Neuroscience and weight problems Sarah F. Leibowitz and Bartley G. Hoebel; Experimental reviews at the regulate of nutrients consumption Henry S. Koopmans; nutrition Composition and the keep watch over of foodstuff consumption in people John E. Blundell and James Stubbs; critical Integration of Peripheral signs within the rules of foodstuff consumption and effort stability: position of Leptin and Insulin L. Arthur Campfield, Fran oise J. Smith, and Bernard Jeanrenaud; improvement of White Adipose Tissue G rard Ailhaud and Hans Hauner; Lipolysis and Lipid Mobilization in Human Adipose Tissue, Dominique Langin and Max LaFontan; Lipodystrophy and Lipoatrophy Steven R. Smith; Uncoupling Proteins Daniel Ricquier and Leslie P. Kozak. (Part contents).

Download e-book for iPad: Microbicides for Prevention of HIV Infection by Jeremy Nuttall

Probably the most promising new methods for the prevention of HIV transmission, fairly for constructing nations, contains topical, self-administered items referred to as microbicides. the improvement of microbicides is a protracted and complex strategy, and this quantity presents an outline of the entire severe components, from the choice of acceptable candidate molecules and their formula, preclinical and medical trying out for safeguard and efficacy, thoughts for product registration and at last, matters linked to product release, distribution and entry.

Additional info for Antimicrobial drug discovery : emerging strategies

Sample text

And Sharma, S. (2009) Peptide deformylase – a promising therapeutic target for tuberculosis and antibacterial drug discovery. Expert Opinion on Therapeutic Targets 13, 753–765. P. R. P. R. (2011) Drug discovery of antimicrobial photosensitizers using animal models. Current Pharmaceutical Design 17, 1303–1319. M. B. (2003) Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infection and Immunity 71, 2208–2217. , Begun, J. M. (2005) The worm has turned – microbial virulence modeled in Caenorhabditis elegans.

2008) A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science 319, 1391–1394. Loeffler, J. A. (2003) Synergistic lethal effect of a combination of phage lytic enzymes with different activities on penicillinsensitive and -resistant Streptococcus pneumoniae strains. Antimicrobial Agents and Chemotherapy 47, 375–377. , Djurkovic, S. A. (2003) Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia. Infection and Immunity 71, 6199–6204. Lomovskaya, O.

Mylonakis, E. R. (2010) Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model. Lasers in Surgery and Medicine 42, 38–44. Daum, R. (2008) Removing the golden coat of Staphylococcus aureus. New England Journal of Medicine 359, 85–87. N. F. (2010) Community-associated meticillinresistant Staphylococcus aureus. Lancet 375, 1557–1568. L. and Sanchez, S. (2009) Microbial drug discovery: 80 years of progress. Journal of Antibiotics 62, 5–16. Demidova, T.

Download PDF sample

Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis

by James

Rated 4.95 of 5 – based on 21 votes